ADAPTIVE DESIGNS IN CLINICAL TRIALS: FROM SCIENTIFIC ADVICE TO MARKETING AUTHORISATION TO THE EUROPEAN MEDICINE AGENCY

Adaptive designs in clinical trials: from scientific advice to marketing authorisation to the European Medicine Agency

Abstract Background In recent years, experience on the application of adaptive designs in confirmatory clinical trials has accumulated.Although planning such trials comes at the cost of additional operational complexity, adaptive designs offer the benefit of flexibility to update trial design and objectives as data accrue.In 2007, the European Medi

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CustodyBlock: A Distributed Chain of Custody Evidence Framework

With the increasing number of cybercrimes, the digital forensics team has no choice but to implement more robust and resilient evidence-handling mechanisms.The capturing of digital evidence, which is a tangible and probative piece of information that can be presented in court and used in trial, Sandwich Makers is very challenging due to its volatil

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